Community-Acquired Pneumonia and Proton Pump Inhibitors

Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis.

This study was presented at the American College of Chest Physicians meeting in Pittsburgh (PA, USA) in October 2011. The study objective was to evaluate the association of proton pump inhibitors (PPIs) and community-acquired pneumonia (CAP). The design was a meta-analysis of nine case-controlled and cohort studies. 120,863 pneumonia cases from 1987 to 2006 were included in the meta-analysis. P...

Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis

OBJECTIVE Previous observational studies suggest that the use of proton pump inhibitors (PPIs) may increase the risk of hospitalisation for community-acquired pneumonia (HCAP). However, the potential presence of confounding and protopathic biases limits the conclusions that can be drawn from these studies. Our objective was, therefore, to examine the risk of HCAP with PPIs prescribed prophylact...

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study

Objective To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association.Design Cohort study and self controlled case series.Setting Clinical Practice Research Datalink (1990 to 2013) in UK.Participants Adult patients with a new prescription for a PPI individually matched with c...

Shreya M. Shah et al RISK OF COMMUNITY ACQUIRED PNEUMONIA WITH PROTON PUMP INHIBITORS: A SYSTEMIC REVIEW

Background: Proton pump inhibitors (PPIs) are widely used over-the-counter drugs for treatment of acid peptic disease. Irrational use of PPIs without proper indication has exposed patients to unnecessary risks. Currently, PPIs are under scrutiny by U.S.FDA to determine risk of community acquired pneumonia (CAP) as conflicting results have been obtained from various studies. Aim: The aim of our ...

Proton Pump Inhibitors: Omeprazole